Biography of Basudev Roy

We are an upcoming group in the Physics department of IIT Madras with primary emphasis on Optical Tweezers based study of statistical mechanics and biological systems. We are essentially going to divide our time for two topics, namely, High Resolution Imaging based systems and Optical Tweezers based systems.

HIGH RESOLUTION IMAGING BASED SYSTEMS
 
We would like to probe biological systems at the single molecule level by performing high resolution imaging. Some examples of high resolution imaging tools are Dark Field Microscopy,  Interference Reflection Microscopy (IRM) and Total Internal Reflection Microscopy (TIRF). We would like to see if simple tools that enhance these techniques can challenge the state of the art in the field, namely the "Super-Resolution Microscopy". 

 

OPTICAL TWEEZERS BASED SYSTEMS

We would like to couple high resolution imaging systems described in the last section to optical tweezers to study biological systems. Optical Tweezers are a tightly focused beam of light which generates a three dimensional potential well for trapping microparticles. These can not only be used to apply and detect controlled forces but also controlled torques upon using birefringent microparticles. We would like to couple single biomolecules like kinesin motors and DNA to such birefringent particles and apply controlled torques to study intrinsic properties of these molecules. A rigid body can have three degrees of rotational freedom, which we call the yaw, the pitch and the roll. The yaw, or the in-plane degree of rotational freedom is well studied in optical tweezers literature. But the pitch and the roll have not. We have done some work in generating and detecting pitch motion with applications to the study of biological problems. 

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NON EQUILIBRIUM STATISTICAL MECHANICS PROBLEMS

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We shall try to probe the interaction among different types of particles in different types of media and see how the exchange of energy takes place for equilibrium and non-equilibrium systems. 

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Invited Talks:

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1. “Study of out-of-plane rotations in optical tweezers with usage in cellular biological systems”, SPIE Optics and Photonics, PC131120H, San Diego, California, USA, August 2024.

2. “Study of Out-of-Plane rotations in optical tweezers with usage in soft matter and biological systems”, Optica Biophotonics Congress: Optics in the life sciences, ATu3D.4, Vancouver, British Columbia, Canada, 25th April 2023.

3. "Study of soft and biological matter systems using optical tweezers", In-House Colloquium, Department of Physics, Indian Institute of Technology Madras, Chennai , 20th October, 2021.

4 "Study of soft matter systems using rotational optical tweezers", Indian Institute of Technology, Tirupati, 30th October 2019. 

5. "Determination of twisting of kinesin molecules during stepping", OSA Biophotonics congress: Optics in the life sciences,  AM2E.1, Tucson, Arizona, 15th April, 2019. 

6.“Optical Tweezers for determination of rotational motion in the mesoscopic domain”, Indian Institute of Science Education and Research, Kolkata, India, 19th Dec 2017. 

7. “Optical Tweezers for determination of rotational motion in the mesoscopic domain”, Institute of Nano Science and Technology, Mohali, India, 18th Sept 2017

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Patents:

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1. “Laser Induced Micro-Bubble Based Patterning of Biological Macromolecules Towards Bio-Sensing Applications”, Subhrokoli Ghosh, Anand Dev Ranjan, Pradyoti Sarkar, Rakesh Sen, Arnab Gupta, Pei Liang, Amirul Mullick, Basudev Roy, Soumyajit Roy, Ayan Banerjee, Provisional patent application no. 202031020734 filed on 18 May 2020.

2. "Development of a Field-Effect Device using conducting polymers such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) layers made using microbubble lithography", Basudev Roy, Ayan Banerjee, Soumya Dutta, Rahul Vaippully, Mithun Ajith, Anand Dev Ranjan, Provisional patent application no. 202141026917 filed on 16 June 2021.

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Journal Publications:

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IIT MADRAS WORK 

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Sub-Judice

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1.

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Published

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AS ASSOCIATE PROFESSOR

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1. Ajith L. Kumar, Snigdhadev Chakraborty, Basudev Roy, Jayaraman Senthilselvan, “Effect of Yb3+ concentration on the upconversion emission properties of sub-10 nm RbY2F7: Yb, Er nanoparticles”, Physical Chemistry Chemical Physics, 26, 25240 (2024).

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2. Thilak Raj, Srestha Roy, Ashwin Kumar, Basudev Roy*, Ethayaraja Mani and Swathi Sudhakar*, “Direct measurement of self-diffusiophoretic force generated by active colloids of different patch coverage using optical tweezers”, Journal of Colloid and Interface Science, 677, 986 (2024). * Equal corresponding author.

3. Srestha Roy, Atanu Ghosh, Muruga Lokesh, Gokul Nalupurackal, Snigdhadev Chakraborty, Jayesh Goswami, Vidya Praveen Bhallamudi, Siddharth Dhomkar* and Basudev Roy*, "Comparison of Optical Trapping wavelengths for Nanoscopic Diamonds containing Nitrogen-Vacancy centers", Journal of Physics Communications, 8, 055001 (2024). *Equal corresponding author

4. Kingshuk Panja, Jayesh Goswami, Gokul Nalupurackal, Snigdhadev Chakraborty, Srestha Roy, Basudev Roy*, Rajesh Singh*, "Nonlinear dynamics of a microparticle in a hydro-thermophoretic trap", Results in Physics, 61, 107709 (2024). *Equal corresponding author

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5. Jayesh Goswami, Snigdhadev Chakraborty, Gokul Nalupurackal, Srestha Roy, and Basudev Roy, "Achievement of Sub-diffractive Detection Depth in Absorption Spectroscopy Using Excitation From an Upconverting Particle", Advanced Photonics Research, 5, 2300292 (2024). 

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6. Gokul Nalupurackal, Jaspal Singh, Srestha Roy, Muruga Lokesh, Snigdhadev Chakraborty, Jayesh Goswami, Arijit Bhattacharya, Pallab Sinha Mahapatra, A.R. Ganesan and Basudev Roy, "Estimation of the proximal temperature rise of an excited upconversion particle by detecting the wavefront of emission", Optics Express, 32, 6011 (2024). 

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7. Snigdhadev Chakraborty, Gokul Nalupurackal, Srestha Roy, Muruga Lokesh, Jayesh Goswami, Gunaseelan, M. , Basudev Roy, "High-resolution detection of pitch rotation in an optically confined hexagonal-shaped upconverting particle", Optics Express, 31, 42230 (2023). 

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8. Anand Dev Ranjan, Rakesh Sen, Sumeet Kumar, Rahul Vaippully, Soumya Dutta, Basudev Roy*, Gautam Dev Mukherjee, Soumyajit Roy*, Ayan Banerjee*, "Interface engineering towards high conductivity of a model organic-plastic micro-surface by microbubble lithography", Journal of Materials Chemistry C, 11, 17061 (2023). *Equal corresponding author. 

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9. Jayesh Goswami, Gokul Nalupurackal, Muruga Lokesh, Srestha Roy, Snigdhadev Chakraborty, Arijit Bhattacharya, Pallan Sinha Mahapatra, Basudev Roy, "Formation of two-dimensional magnetically responsive clusters using Haematite particles self-assembled via particle induced heating at an interface", Journal of Physical Chemistry B, 127, 8487 (2023). 

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10. Urvashi Nakul, Srestha Roy, Gokul Nalupurackal, Snigdhadev Chakraborty, Priyanka Siwach, Jayesh Goswami, Privita Edwina, Saumendra Bajpai, Rajesh Singh, Basudev Roy, "Studying fluctuating trajectories of optically confined tracers within cells provides familiar active forces", Biomedical Optics Express, 14, 5440 (2023). 

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11. Gokul Nalupurackal, Kingshuk Panja, Snigdhadev Chakraborty, Srestha Roy, Jayesh Goswami, Basudev Roy*, Rajesh Singh*, "Controlled roll rotation of a microparticle in a hydro-thermophoretic trap", Physical Review Research, 5, 033005 (2023). 

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12. Snigdhadev Chakraborty, Gokul Nalupurackal, Gunaseelan M., Srestha Roy, Muruga Lokesh, Jayesh Goswami, Priyankan Datta, Pallab Sinha Mahapatra, Basudev Roy, " Facets of optically and magnetically induced heating in ferromagnetically doped-NaYF$_4$ particles", Journal of Physics Communications, 7, 065008 (2023). 

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13. Gokul Nalupurackal, Muruga Lokesh, Sarangi Suresh, Srestha Roy, Snigdhadev Chakraborty, Jayesh Goswami, Gunaseelan M., Arnab Pal, Basudev Roy, "Towards Stirling engine using an optically confined particle subjected to asymmetric temperature profile", New Journal of Physics, 25, 063001 (2023). 

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14. Srestha Roy, Rahul Vaippully, Muruga Lokesh, Gokul Nalupurackal, Vandana Yadav, Snigdhadev Chakraborty, Manoj Gopalakrishnan, Privita Edwina, Saumendra Bajpai, Basudev Roy, "Comparison of thermal and athermal dynamics of the cell membrane slope fluctuations in the presence and absence of Latrunculin-B", Physical Biology, 20, 046001 (2023). 

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15. Gokul Nalupurackal, M. Gunaseelan, Muruga Lokesh, Rahul Vaippully, Amit Chauhan, B.R.K. Nanda, Sudakar Chandran, Hema Chandra Kotamarthi, Priyankan Datta, Pallab Sinha Mahapatra, Anita Jannasch, Erik Schaffer, Jayaraman Senthilselvan, Basudev Roy, "Simultaneous optical trapping and electromagnetic micromanipulation of ferromagnetic doped-NaYF4 microparticles", ACS Applied Optical Materials, 1, 615 (2023). 

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16. Muruga Lokesh, Gokul Naupurackal, Srestha Roy, Snigdhadev Chakraborty, Jayesh Goswami, Gunaseelan M., Imdad Uddin Chowdhury, Vidya P. Bhallamudi, Pallab Sinha Mahapatra and Basudev Roy "Accelerated self assembly of particles at the air-water interface with optically assisted heating due to an upconverting particle", Optics Express, 31, 5075 (2023). 

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17. Srestha Roy, Rahul Vaippully, Muruga Lokesh, Gokul Nalupurackal, Privita Edwina, Saumendra Bajpai and Basudev Roy,  "Comparison of translational and rotational modes towards passive rheology of the cytoplasm of MCF-7 cells using optical tweezers", Frontiers in Physics, doi:10.3389/fphy.2022.1099958 (2023).

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18. Giovanni Volpe, Onofrio Marago, Halina Rubinstein, ....., Rahul Vaippully, Muruga Lokesh, Basudev Roy, ...., G. Swartzlander, "Roadmap for optical tweezers 2023", Accepted in Journal of Physics Photonics (2023).

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AS ASSISTANT PROFESSOR

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1. Privita Edwina, Sumeet Kumar, Srestha Roy, Basudev Roy and Saumendra Bajpai, "Anisotropic 3D confinement of MCF-7 cells induces directed cell-migration and viscoelastic anisotropy of cell-membrane", Physical Biology, 20, 016003 (2022).

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2.Gokul Nalupurackal, M. Gunaseelan, Srestha Roy, Muruga Lokesh, Sumeet Kumar, Rahul Vaippully, Rajesh Singh and Basudev Roy, "A hydro-thermophoretic trap for microparticles near a gold-coated substrate", Soft Matter, 18, 6825 (2022). 

3. Muruga Lokesh, Gokul Nalupurackal, Srestha Roy, Snigdhadev Chakraborty, Jayesh Goswami, M. Gunaseelan, Basudev Roy, “Generation of partial roll rotation in a hexagonal NaYF4 particle by switching between optical trapping configurations”, Optics Express, 30, 28325 (2022).

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4. S.Yamini, M.Gunaseelan, G.A.Kumar, Gamage Chamath Dannangoda, Karen S Martirosyan, Dhiraj K Sardar ,  Basudev Roy and J.Senthilselvan, " Tailoring the upconversion emission and magnetic properties of NaGdF4:Yb,Er by Mg2+ or Fe3+ doping and optical trapping of individual magnetic nanoparticle at NIR 980 nm", Ceramics International, 48, 24003 (2022). 

5. Merin Jose, Muruga Lokesh, Rahul Vaippully, Dillip Satapathy and Basudev Roy, "Temporal evolution of viscoelasticity of soft colloid laden air-water interface: A multiple mode microrheology study", RSC Advances, 12, 12988 (2022). 

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6. Muruga Lokesh, Rahul Vaippully, Vidya P. Bhallamudi, Anil Prabhakar, Basudev Roy, "Realisation of pitch-rotational torque wrench in two-beam optical tweezers", Journal of Physics Communications, 5, 115016 (2021).

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7. Selvam Yamini, M Gunaseelan, A Gangadharan, S.A. Lopez, Martirosyan K. S., A. Girigoswami, Basudev Roy, J. Manonmani, Jayaraman Senthilselvan, "Upconversion, MRI Imaging and Optical Trapping Studies of Silver Nanoparticle Decorated Multifunctional NaGdF4:Yb,Er Nanocomposite", Nanotechnology, 33, 085202 (2022).

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8. Muruga Lokesh, Rahul Vaippully, Gokul Nalupurackal, Srestha Roy, Vidya P. Bhallamudi, Anil Prabhakar and Basudev Roy, "Estimation of rolling work of adhesion at the nanoscale with soft probing using optical tweezers", RSC Advances, 11, 34636-34642 (2021).

Highlighted in Tech Talks by IIT Madras

https://tech-talk.iitm.ac.in/roll-with-it/

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9. Vaibavi Ramanujam, Manoj Sivasubramaniapandian, Rahul Vaippully, Privita Edwina, Basudev Roy, Saumendra Bajpai, "Calcium-channel blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells", Cell Biochemistry and Biophysics, 80, 171-190 (2022).

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10. Amrendra Kumar, Gunaseelan M., Gaurav Vaidya, Rahul Vaippully and Basudev Roy, "Estimation of motional parameters using emission from upconverting nanoparticles optically trapped at the absorption resonance", Accepted In European Physical Journal-Special Topics (2021). 

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11. Rahul Vaippully, Lokesh Muruga and Basudev Roy, "Continuous rotational motion in birefringent particles using two near-orthogonally polarized optical tweezers beams at different wavelengths with low ellipticity", Journal of Optics, 23, 094001 (2021).

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12. Sumeet Kumar, Gunaseelan M., Rahul Vaippully, Ayan Banerjee and Basudev Roy, "Breaking the diffraction limit in absorption spectroscopy using upconverting nanoparticles", Nanoscale, 13, 11856 (2021). 

Highlighted in "The Hindu" newspaper.

https://www.thehindu.com/sci-tech/science/new-technique-to-study-ultrasmall-particles-in-cells/article35788908.ece

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13. Subhrokoli Ghosh, Anand Dev Ranjan, Santu Das, Rakesh Sen, Basudev Roy, Soumyajit Roy and Ayan Banerjee, "Directed self-assembly driven meso-scale lithography using laser-induced and manipulated microbubbles: complex architectures and diverse applications", Nano Letters, 21, 10 (2020). 

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14. Sumeet Kumar, Amrendra Kumar, Gunaseelan M., Rahul Vaippully, Dipanjan Chakraborty, Jayaraman Senthilselvan and Basudev Roy, "Trapped in out-of-equilibrium stationary state: Hot Brownian motion in optically trapped upconverting nanoparticles", Frontiers in Physics, 8, 570842 (2020). 

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15. Rahul Vaippully, Vaibavi Ramanujan, Manoj Gopalakrishnan, Saumendra Bajpai, Basudev Roy, "Detection of sub-degree fluctuations of the local cellmembrane slope using optical tweezers", Soft Matter, 16, 7606  (2020).  

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16. Sumeet Kumar, M. Gunaseelan, Rahul Vaippully, Amarendra Kumar, Mithun Ajith, Gaurav Vaidya, Soumya Dutta and Basudev Roy,"Pitch-rotational manipulation of single cells and particles using single-beam thermo-optical tweezers", Biomedical Optics Express, 11, 3555 (2020). 

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17. Rahul Vaippully, Vaibavi Ramanujan, Saumendra Bajpai and Basudev Roy,"Measurement of viscoelastic properties of the cellular cytoplasm using optically trapped Brownian probes"",  Journal of Physics Condensed Matter, 32, 235101 (2020).

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18. Muruga Lokesh, Rahul Vaippully, Basudev Roy, "Active generation of pitch degree of rotational motion in optical tweezers", Asian Journal of Physics, 29, 177 (2020). 

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19. L. Anbharasi, E. A. Bhanu Rekha, Rahul Vaippully, Basudev Roy, M Gunaseelan, S. Yamini, Venkata N.K.B .Adusumalli, Debashrita Sarkar, Venkataramanan Mahalingam, J. Senthilselvan, "Tunable Emission and Optical Trapping of Upconverting LiYF4:Yb,Er Nanocrystal", Optics and Laser Technology, 126, 106109 (2020).

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20. Rahul Vaippully, Venkata Siva Gummaluri, C Vijayan and Basudev Roy, “Validity of cylindrical approximation for spherical birefringent microparticles in rotational optical tweezers”, Journal of Physics Communications, 4, 015005 (2020).

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21. Dhanush Bhatt, Rahul Vaippully, Bhavesh Kharbanda, Anand Dev Ranjan, Sulochana K., Viraj Dharod, Dillip Satapathy and Basudev Roy, "Detection of self-generated nanowaves on the interface of an evaporating sessile water droplet", Optics Express, 27, 31900 (2019).

Highlighted in

"Down to Earth". https://www.downtoearth.org.in/news/science-technology/study-peeks-into-thermal-mechanisms-of-droplet-type-cooling-for-microchips-67594

"Vigyan Prasar", https://vigyanprasar.gov.in/isw/Study-provides-insights-into-thermal-mechanisms-of-droplet-type-cooling-for-microchips.html

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22. Rahul Vaippully, Dhanush Bhatt, Anand Dev Ranjan and Basudev Roy, " Study of adhesivity of surfaces using rotational optical tweezers", Physica Scripta,, 94, 105008 (2019).

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23. Basudev Roy*, Avin Ramaiya and Erik Schaffer, “Determination of pitch rotation in a spherical birefringent microparticle”, Journal of Optics, 20, 035603  (2018). * Corresponding author.

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SELECTED PREVIOUS WORK

1. Mayank Chugh, Maja Reissner, Michael Bugiel, Elisabeth Lipka, Arvid Herrman, Basudev Roy, Sabine Muller, Erik Schaffer, "Phragmoplast Orienting Kinesin 2 Is a Weak Motor Switching between Processive and Diffusive Modes", Biophys. J, 115, 375 (2018). 

2. Avin Ramaiya*, Basudev Roy*, Michael Bugiel and Erik Schaffer, “Kinesin rotates unidirectionally and generates torque while walking on microtubules”, Proceedings of National Academy of Sciences, 114, 10894 (USA) (2017).Highlighted in Science Daily.     https://www.sciencedaily.com/releases/2017/09/170926091425.htm

3. Subhrokoli Ghosh, Santu Das, Shuvojit Paul, Preethi Thomas, Basudev Roy, Partha Mitra, Soumyajit Roy, Ayan Banerjee, “In-situ self-assembly and photopolymerization for hetero-phase synthesis and patterning of conducting materials using soft-oxometalates in thermo-optical tweezers”, Journal of Materials Chemistry C, 5, 6718 (2017). Highlighted in Nature India, India Today, Business Standard.

http://www.natureasia.com/en/nindia/article/10.1038/nindia.2017.90

http://indiatoday.intoday.in/story/indian-scientists-use-tiny-bubbles-to-draw-plastic-circuits/1/1014970.html 

4. Preethi Thomas, Cuiying Pei, Basudev Roy, Ayan Banerjee, Teng Ben, ShilunQiu and Soumyajit Roy,  “Site specific supramolecular heterogenous catalysis by optically patterned soft-Oxometallate-Porous Organic Framework (SOM-POF) hybrid on a chip”, J. Mater. Chem. A, 3, 1431 (2015).

5. Basudev Roy, Manish Arya, Preethi Thomas, Julius Constantin Jurgschat,  Venkat Rao, Ayan Banerjee, Chilla Malla Reddy and Soumyajit Roy, “Controlled and continuous patterning of organic and inorganic materials by induced nucleation in an optical tweezers”,  Langmuir, 29,14733 (2013).

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Funding Sources

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1. Wellcome Trust-Department of Biotechnology India Alliance

2. IMPRINT program SERB, DST

3. IIT Madras, Seed, Initiation and Exploratory Grants. 

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PhD Students (Thesis Defended and Submitted):

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1. Sumeet Kumar 

2. Rahul Vaippully (Got the Alexander von Humboldt Fellowship to pursue postdoctoral research at the University of Tuebingen)

3. C.M. Lokesh (Got the Alexander von Humboldt Fellowship to pursue postdoctoral research at University of Konstanz)

4. Urvashi Nakul (Co-guided with Manoj Gopalakrishnan)

5. Amrendra Kumar

6. Gokul Nalupurackal

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PhD Students (Ongoing):

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1. Sreshtha Roy

2. Jayesh Goswami

3. Snigdhadev Chakraborty

4. Atanu Ghosh (Co-guiding with Siddharth Dhomkar)

5. Vimal Parashar (Co-guiding with Saumendra Bajpai)

6. Mrityunjay Kumar

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BTech, MSc and MTech Students (Thesis work completed)

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1. Akshay Kumar Bardhan

2. Debashis Mondal

3. A. Sahal

4. J. Shravan Kumar

5. Mukul Sagar

6. Ayan Kumar Garai

7. Uma Shankar

8. Sarangi Suresh

9. Snigdhadev Chakraborty

10. Bhaskar De

11. Dhanush Bhatt

12. Bhavesh Kharbanda

13. Ponnapati Anvitha